Domperidone + paracetamol

Hypersensitivity. GI haemorrhage, obstruction and perforation, patients with prolactin releasing pituitary hormone or chronic admin or for prophylaxis of postoperative nausea and vomiting.

Phaeochromocytoma; children, elderly; renal or hepatic impairment, risk of cardiac arrhythmias and hypokalaemia if administered IV. Pregnancy, lactation and alcohol-dependent patients.

Drowsiness, extrapyramidal reactions, galactorrhoea, gynaecomastia; constipation or diarrhoea, lassitude, decreased libido, nausea, allergic reactions, skin rashes, acute renal tubular necrosis.
Potentially Fatal: Domperidone: convulsions, arrhythmias and cardiac arrest, dysrhythmias in patients with CV disease or hypokalaemia, patients on cancer chemotherapy. Seizures, hypertensive crisis in patients with pheochromocytoma are seen.
Paracetamol, very rare, blood dyscrasias (eg, thrombocytopaenia, leucopaenia, neutropaenia, agranulocytosis); liver damage are seen.

Domperidone reduces absorption of oral digoxin, increases absorption of aspirin and oral diazepam. Enhances CNS depression by phenothiazines. Antimuscarinic agents and opioids antagonise GI effects of domperidone.
Paracetamol reduced absorption of cholestyramine within 1 hr of admin and accelerates absorption of metoclopramide.

Antimigraine Preparations

A03FA03 - domperidone ; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.
N02BE01 - paracetamol ; Belongs to the class of anilide preparations. Used to relieve pain and fever.